DNA repair requires the timidly expression of DNA repair proteins and metabolites required for the process of synthesizing new DNA.
Biomarkers are molecules produced by the cancer cells or by other cells in the body in response to cancer. They can be found in the tumor tissue and in several other compartments like blood and ur
The bioenergetic activity of cells is controlled by the energy (ATP) demand and coordinated by signal transduction pathways and transcription factors that directly modulate nutrient uptake and meta
We study the mechanism that cancer cells employ to cope with molecular stress, in particular the stress generated from DNA replication and metabolism.
My lab, with a team of collaborators, contributed to establish the role of mRNA metabolism in sustaining oncogene program expression.
This projects aims to determine the molecular basis of an epigenetically encoded mechanism of chemotherapy resistance in aggressive lymphomas and its reversal by demethylating agents.